Fall 2025 Post Doctoral Fellow - Peptide Synthesis

Job Title: Fall 2025 Post Doctoral Fellow - Peptide Synthesis

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

Join our dynamic team at Sanofi as a Postdoctoral Research Fellow focused on advancing the field of peptide synthesis as it relates to pharmaceutical and process development. In this role, you will contribute to a research area that centers on revolutionizing drug development by incorporating techniques of both solution-phase and solid-phase peptide synthesis (SPPS).

Specifically, this post-doctoral role is focused on: (1) developing a platform that establishes a workflow for route invention for peptide-derived drug substances and (2) applying lessons learned to scalable and process-friendly reaction development as it relates to the incorporation of noncanonical amino acids into larger peptides.

We are seeking an ambitious and innovative researcher who is passionate about pushing the boundaries of peptide synthesis. If you are excited about contributing to the development of state-of-the-art reaction design and process development within this discipline, we encourage you to apply and be part of our collaborative and forward-thinking research team at Sanofi.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

• Build a workflow for peptide synthesis within Sanofi CMC. This requires the implementation of new equipment and technologies and corresponding analytical techniques. Understanding of how the platform will be optimized for ease of use, speed and execution.

• New reaction development involving peptides emphasizing the incorporation of noncanonical amino acids.

• Design, plan and execute experimental plans, optimize reactions, purification and isolation unit operations, guided by technical risk assessments, to deliver safe, efficient, robust and scalable drug substance manufacturing processes that perform reliably at intended scale in batch or continuous format.

• Provide concise technical presentations to communicate work to project teams, cross functional teams and management. Document all work on projects and continuous improvements in eLNB experiments and summarize in technical reports

• Communicate scientific results/findings in an academic journal, patent or presentation.

About You

Basic Qualifications:

• Must hold or receive a Ph.D. in chemistry, chemical biology, or a related field from an accredited university by the time of the start date

• Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the PostDoc role.

Preferred Qualifications:

• Proficient understanding of synthetic reaction transformations and in-depth expertise in mechanistic and retrosynthetic analysis.

• Expertise in various methods surrounding peptide synthesis: SPPS, liquid-tagged synthesis, solution-phase synthesis.

• Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire).  

• Excellent written and oral communication skills

• Must have permanent US work authorization

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.