Senior Principal Scientist, Type 2 Immunology

Job title: Senior Principal Scientist Type 2 Immunology

Location:Cambridge, MA

About the Job

Immunology and Inflammation Therapeutic Area
We have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology cluster. This role sits at the intersection of cutting-edge preclinical research and clinical development, offering a unique platform to shape the trajectory of one of the industry's most compelling immunology portfolios. Working at our Cambridge Crossing research campus, you will contribute to a team with deep commitment to scientific excellence and patient impact across dermatology, gastroenterology, respiratory, and rheumatology.

This position carries a dual mandate. Leading preclinical research programs from hypothesis generation through execution, while also serving as to support early clinical and/or late-stage or marketed product programs. In this capacity, you will drive translational research strategies that inform clinical development and support lifecycle management initiatives for assets. You will integrate insights from clinical studies back into research strategy, ensuring a continuous and productive dialogue between both early research, clinical development and medical affairs.

The successful candidate will leverage Sanofi's extensive technical capabilities, including AI enabled platforms, single cell technologies, and multiomic approaches, while collaborating closely with Development, Medical Affairs, and Commercial teams. This is an opportunity to make a meaningful scientific and strategic contribution within a highly collaborative, cross functional environment.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world.

Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Lead preclinical research programs from hypothesis generation through experimental execution, integrating findings into broader clinical strategy. 
• Directly support early clinical and or late stage or marketed product programs, translating clinical insights back to research and driving translational strategies to support clinical decision making and asset life cycle management. 
• Design and execute research programs in close partnership with Development, Medical Affairs, and Commercial teams as part of IEGP to maximize the value of Sanofi's portfolio.
• Independently formulate research hypotheses and apply scientific expertise to design and execute experiments using murine and human immunology approaches. 
• Develop novel in vitro and in vivo assays and apply advanced technologies including single cell approaches (flow cytometry, scRNAseq), multiomics, and imaging platforms. 
• Lead cross functional collaborations and manage stakeholder relationships effectively across a matrixed global organization. 
• Communicate research findings clearly and compellingly to diverse audiences, both technical and nontechnical, internal and external. 
• Mentor and actively support the scientific and professional development of junior team members. 
• Stay at the forefront of scientific advances and contribute to the strategic direction of the group. 
• Maintain laboratory activity while providing scientific leadership; this role has an expectation of bench engagement as necessary.
• Ensure adherence to safety standards, laboratory conduct, diligent ELN record keeping and Sanofi's code of conduct.

About You

Basic Qualifications:

• PhD in Immunology, neuroimmunology, molecular biology, pharmacology or related fields with 8+ years of relevant experience in an academic or biopharmaceutical setting. Or equivalent: Master's + 10 years of experience; Bachelor's + 12 years of experience).
• Demonstrated experience leading preclinical research projects or key contributor on early clinical and/or late-stage or marketed product programs, this is a critical requirement for this role
• Proven track record in translational research supporting clinical development and/or lifecycle management 
• Strong expertise in human and murine immunology and inflammatory disease pathways 
• Experience with advanced technologies including single cell approaches (flow cytometry, scRNA-seq), molecular techniques, and multi-omic platforms 
• Proven ability to work collaboratively in cross-functional, matrixed environments with Development, Medical Affairs, and/or Commercial teams 
• Excellent stakeholder management and communication skills across diverse audiences 
• Strong team player with a collaborative mindset and genuine commitment to supporting others 
• Demonstrated mentorship capabilities and track record of developing junior scientists
• Record of scientific publications and presentations in high impact peer-reviewed journals
• Experience with external academic collaborations and working with CRO

Preferred Qualifications:

• Direct experience in Type 2 inflammatory diseases (dermatology, respiratory, GI, rheumatology)
• Experience with clinical biomarker strategy development and implementation
• Hands-on experience with human tissue biopsies (skin, lung, gut), mouse disease models, and or organoid systems
• Experience contributing to regulatory submissions or clinical trial design

Why Choose Us? 

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.