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Sanofi is seeking a highly motivated senior scientist to join our mass spectrometry analytical laboratory. This laboratory is part of the Synthetic platform within the Global CMC Department that is striving to become an industry leader in the development of transformative medicines. 

The primary responsibility of this position is to perform structural characterization by interpretation of fragmentation mass spectra of synthetic small molecules and to manage analytical CMC projects. This position is onsite and is based in Sisteron, France. 

Main Responsibilities :

• Develop and implement UPLC/HRMS (Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) : Electrospray Ionization (EI) and Atmospheric Pressure Chemical Ionization (APCI) and GC/MS (Gas Chromatography / Mass Spectrometry) : Electron Ionization and Chemical Ionization methods for the structural characterization by interpretation of fragmentation mass spectra of synthetic small molecules (active pharmaceutical ingredient, process intermediates, impurities and degradants) in the context of chemical development projects, analytical expertise and production troubleshooting
• Develop, validate UPLC/HRMS ( Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) and GC/MS (Gas Chromatography / Mass Spectrometry) based quantitation methods for small molecules (ultratraces, mutagenic molecules, nitrosamines…) including writing of the documentation (protocols, reports, methods)
• Ensure the reliability and traceability of results obtained. Can review analytical experiences performed by expert mass spectrometry technicians
• Manage projects as a local analytical representative or as an Analytical Team Leader in project teams. Represent your unit or department within project teams and during internal scientific presentations
• Take part in project meetings with collaborators in other teams, departments and countries. The oral and written communication in French and in English is not a problem!
• Write the corresponding analytical section for clinical and submission dossier
• Propose and lead innovation initiatives, individually or in a team, in the mass spectrometry domain, propose innovative solutions for increased efficiency and ensure their visibility internally (meetings, events) and externally (publications, conferences, seminars)
• Manage equipment park (UPLC/HRMS and GC/MS) to insure performance maintenance and systems qualification

About you

Education:

• Master degree or analytical chemistry Engineer (or equivalent) with significant experience more than 8 years or PhD in analytical chemistry with more than 4 years of significant experience (with interpretation of fragmentation mass spectra of synthetic small molecules skills)

Experience:

• Specialized in high-resolution mass spectrometry for structural analysis (interpretation of fragmentation mass spectra (Full scan, MSn)
• Development and validation of UPLC/MS ( Ultra Performance Liquid Chromatography / High Resolution Mass Spectrometry) and GC/MS (Gas Chromatography / Mass Spectrometry) methods for the quantitation of ultratraces, mutagenic molecules and nitrosamines in different matrices
• Expertise in pharmaceutical analytical development
• Project management
• Resolution of complex topics
• Redaction of scientific reports and articles

Technical Skills:

• Excellent knowledge in gas and liquid chromatography coupled with PDA and MS detection (Orbitrap, QTof, Triple Quad, etc.)
• Good knowledge of spectrometric data processing software (Xcalibur, Freestyle, Chromeleon, etc.)
• Advanced knowledge in interpretation of fragmentation mass spectra (LC/MS and GC/MS) of small molecules
• Good knowledge of projects management to drive the analytical part of projects
• Knowledge in GMP rules
• Knowledge of organic chemistry

Soft skills:

• Team spirit
• Autonomy, decision-making and initiative-making
• Communication skills to interact with internal and external partners
• Curiosity and adaptability for the use of new equipment, digital tools and modeling as well as in the automation and use of artificial intelligence

Languages:

• French and English: Fluent (write, read and communicate)

Why choose us?

• Bring the miracles of science to life alongside a supportive, future-focused team
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave

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