R&D
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Job Title: Sr. Scientist –Molecular, Cellular and In vivo Expert in Rare Neurodevelopmental Disorders

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

We are seeking a highly motivated and skilled scientist with deep expertise in neurodevelopmental diseases biology, combined with strong in vivo and in vitro skills associated to disease models. The ideal candidate will bring robust hands-on experience in vivo and in vitro skills to support phenotypical assessment of neurodevelopmental disease animal models as well as to lead exploration of novel pathways and targets. We are a team that encourages creativity and proactiveness to unlock new therapeutic avenues. This is an exciting opportunity to make an early and meaningful impact on therapies for patients with devastating neurodevelopmental diseases.

In this role, you will lead efforts to discover and validate novel RNA-based therapeutic targets and strategies. Your work will play a critical role in advancing our rare disease pipeline, particularly in rare neurodevelopmental indications. You will collaborate closely with cross-functional teams to translate scientific insights into new programs, contributing to the strategic expansion of our therapeutic portfolio.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Drive new program initiation by applying expertise in neurodevelopmental disorders mechanisms and RNA biology

• Design, develop and conduct in vitro and in vivo mechanism-of-action, and proof-of-concept studies to validate targets and evaluate therapeutic strategies

• Contribute to interdisciplinary research programs in a highly collaborative manner across internal groups and with external partners, with opportunity to grow into a project leadership role

• Prepare high-quality analyses, interpretation, documentation, and presentations to support project milestones, publications, patent filings, and potentially regulatory (IND/CTA) filings

• Present findings and progress in internal meetings and external venues as appropriate (e.g., publications, conferences, collaboration and governance meetings)

About You

Basic Qualifications:

• Ph.D. or equivalent advanced degree in Molecular Biology, Cellular Biology, In vivo Biology or a related discipline, with 3+ years of relevant experience in a biopharmaceutical or academic research setting

• Deep expertise in neurodevelopmental diseases biology and in vivo and in vitro models

• Expertise in RNA homeostasis including RNA regulation and processing (e.g., splicing, stability, transport), the roles of regulatory RNAs and translation regulation mechanism

• Demonstrated ability to produce high-quality scientific documentation, including experimental protocols, standard operating procedures (SOPs), technical reports, and presentations

• Proven track record of meaningful contributions to research programs, evidenced by scientific publications and/or presentations

Preferred Qualifications:

• Hands-on experience with disease-relevant in vivo models, including functional and phenotypic assays such as Electroencephalogram (EEG), Paired-Pulse Facilitation assay (PPF), SYNaptic Proximity Ligation Assay (SYNPLA), field excitatory postsynaptic potentials (fEPSPs), synaptic plasticity measurement techniques, behavior, cognitive and motor functional assays

• In vitro skills: Proficiency in iPSC culture, imaging microscopy, and high throughput imaging microscopy, in vitro neuronal activity (Microelectrodes array plate), Calcium imaging

• Molecular skills: gene expression analysis (qPCR, ddPCR, WB, ELISA/MSD), molecular cloning, vector design, gene editing (e.g., CRISPR)

• Experience with discovery, optimization, and development of small molecules and/or  oligonucleotides

• Familiarity with drug discovery and development processes

Skills and competencies:

• Ability to work independently and collaboratively within cross-functional, matrixed teams

• Highly adaptable, with strong multitasking skills and the ability to manage shifting priorities and timelines

• Strong analytical and problem-solving skills with sound scientific judgment

• Clear written and verbal communication skills, with the ability to convey complex concepts clearly

• Interpersonal strengths that foster effective collaboration and the ability to build productive working relationships

• Outstanding organizational skills, attention to detail, and commitment to maintaining rigorous documentation

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discovery Extraordinary.

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