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Job Title: Principal Scientist, Functional Genomics

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

We are seeking a highly motivated and creative scientist to join the Functional Genomics cluster within the Target, Disease, and Systems Biology function in Sanofi Research. They will drive the implementation and application of emerging functional genomics approaches such as Perturb-seq that couple large-scale perturbation of targets with deep cellular characterization in order to elucidate disease mechanisms and discover novel targets across immunology, ophthalmology, neurology, oncology, and rare disease. The successful candidate will collaborate closely with computational colleagues to advance a ‘lab-in-a-loop’ approach integrating cutting-edge AI with advanced functional genomics. This is a unique opportunity to work at the intersection of functional genomics, AI, and disease biology to advance therapeutic target discovery.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Design and execute high-throughput, multi-modal functional genomics experiments such as Perturb-seq, including cell culture and genetic perturbation.

• Innovate in functional genomics technology by refining experimental methodologies to systematically explore gene function in disease contexts.

• Collaborate closely with therapeutic area and computational biology experts to advance therapeutic discovery and the application of AI to functional genomics in a ‘lab-in-a-loop’.

• Communicate your work through scientific publications, patent and regulatory filings, and presentations at internal and external meetings.

• Support the personal and technical development of junior staff members.

About You

• Ph.D. in genomics, molecular biology, cell biology, systems biology, or related field

• 5 years post-doctoral training and/or equivalent industry experience.

• Experience applying cutting-edge functional genomics tools to target or drug discovery, especially in immunology, ophthalmology, or neurology, is key.

• Hands-on experience in disease modeling in primary cells, iPSC-derived cells, and/or organoids would be highly valued.

• Experience in high-throughput assay development, screening platforms and robotics, flow cytometry, imaging, single cell or spatial genomics, and/or computational data analysis would also be valued.

• Excellent communication, organizational, and team skills with a track record of success working collaboratively across disciplines.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discovery Extraordinary.

Werde Teil von Sanofi und starte mit uns in eine neue Ära der Wissenschaft – wo dein persönliches Wachstum genauso wegweisend ist wie unsere Arbeit. Wir investieren in dich, damit du weiterkommst, schneller denkst und Dinge möglich machst, die vorher undenkbar waren. Du wirst Grenzen verschieben, Gewohntes hinterfragen und smarte Lösungen entwickeln, die direkt bei den Menschen ankommen, für die wir da sind. Bereit, die Wunder der Wissenschaft zu jagen und Leben zu verbessern? Dann lass uns gemeinsam Großes bewegen – und das Außergewöhnliche entdecken.

Bei Sanofi stehen allen die gleichen Chancen offen – unabhängig von Herkunft, Hautfarbe, Religion, Geschlecht, Nationalität, sexueller Orientierung, Alter, Staatsangehörigkeit, Familienstand, Behinderung, Geschlechtsidentität, Veteranenstatus oder anderen gesetzlich geschützten Merkmalen.