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Manufacturing and Supply

Manufacturing and Supply
Where the
miracles of
science
are made
a reality
for patients

Head of Site OpEx and Smart Factory

Waterford, Ireland
Apply now

At a glance

Our teams produce and deliver over 4 billion units of medicines and vaccines every year, ensuring every breakthrough gets to the people who need it most.
Our state-of-the-art facilities, AI-powered smart factories, and cutting-edge automation are redefining what’s possible: ensuring treatments reach patients faster, safer, and more sustainably than ever before. This is where your skills, ambition, and passion can shape the future of healthcare.

  • Title: Head of Site OpEx and Smart Factory
  • Location: Waterford

About Waterford

For more than 20 years, our Waterford team has continued to grow and diversify to serve patients around the world. Today, a team of over 900 work together at a state-of-the-art biopharmaceutical and medical device campus. Recognised through multiple local and national awards, Sanofi Waterford offers flexible working and access to a world of opportunities to grow your career at one location. As well as attractive benefits, the team enjoy access to an onsite gym and medical centre that underpin a strong commitment to health and wellbeing.

Transform Manufacturing Excellence at One of the World's Leading Pharmaceutical Companies

Join Sanofi, a global healthcare leader dedicated to chasing the miracles of science to improve people's lives. At our state-of-the-art Waterford facility, we're revolutionizing pharmaceutical manufacturing through cutting-edge smart factory solutions and operational excellence. We're seeking an exceptional Head of Site OpEx and Smart Factory to lead our transformation journey and drive manufacturing excellence to new heights.

About the Role

As Head of Site OpEx and Smart Factory, you'll be at the forefront of modernizing industrial practices to achieve manufacturing excellence. This Level 4.2 leadership position offers the unique opportunity to combine innovative digital solutions with workforce expertise to reshape Sanofi's manufacturing capabilities. Reporting directly to the Site Head, you'll embody Sanofi's culture of industrial excellence through our Manufacturing System, prioritizing customer service, continuous improvement, and optimization across our operations.

You'll lead a dynamic team focused on performance transformation, digital innovation, and smart factory deployment while fostering a culture of excellence throughout the organization.

Key Responsibilities:

Strategic Leadership & Performance Excellence

  • Develop and Own Site Performance Roadmap: Lead strategy cascading processes with internal and external stakeholders, define Critical Business Needs (CBNs), and drive benchmarking to identify performance gap.
  • Drive Performance Ambition Delivery: Execute transformation initiatives, deploy SMS 2.0 ecosystem, and implement Smart Factory solutions including AI with comprehensive change management
  • Lead Performance Governance: Manage operational KPIs (+QDCI) with cascaded reviews from shopfloor to Senior Leadership Team, ensuring financial impact maximization.
  • Drive Supplier Excellence: Own material and supplier improvement initiatives, serve as business interface for procurement activities
  • Master Data Management: Lead Data & Processes teams and Data Stewards, ensuring data accuracy and analytical capabilities

Smart Factory Transformation & Innovation

  • Champion Smart Factory Roadmap: Collaborate with Digital teams, Global Functions, and Business Owners to define prioritized digital project portfolios
  • Lead Smart Factory Project Implementation: Drive implementation of critical systems (iShift, MARS, LIMS) with comprehensive execution planning and stakeholder management
  • Deploy Smart Factory & GenAI Solutions: Partner with Product Owners and Digital teams for technical implementation, adoption, and value capture

Team Leadership & Capability Development

  • Build High-Performance Teams: Implement Site OpEx & Smart Factory organization, modernize capabilities with rolel profiles (Data Analytics, AI, Connectivity)
  • Develop Talent: Drive OpEx and Smart Factory training programs, foster relationships with global OpEx community

About You

To excel in this role, you will need to have:

Essential Qualifications

  • Advanced Degree in Engineering, Operations Management, or related technical field
  • 10+ years of progressive leadership experience in manufacturing operations, operational excellence, or digital transformation
  • Proven track record in leading large-scale transformation initiatives and performance improvement programs
  • Strong expertise in Lean Manufacturing, Six Sigma, and continuous improvement methodologies
  • Digital transformation experience with Smart Factory technologies, AI implementation, and data analytics
  • Exceptional leadership skills with experience managing cross-functional teams and driving cultural change

Preferred Qualifications

  • Pharmaceutical/Life Sciences industry experience with understanding of GMP requirements
  • Advanced certifications in Lean Six Sigma (Black Belt or Master Black Belt)
  • Project management certification (PMP, PRINCE2, or equivalent)
  • Experience with ERP systems and manufacturing execution systems
  • Strong financial acumen with budget management and business case development experience

Key Competencies

  • Strategic thinking and execution excellence
  • Change management and transformation leadership
  • Data-driven decision making and analytical skills
  • Stakeholder management and communication
  • Innovation mindset with digital fluency
  • Results-oriented with strong business acumen

Pursue progress. Discover extraordinary.

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

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Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com

Apply now
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Find out more about this location

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Why work with us

  • We’re problem-solvers and pioneers. United by the belief that everyone deserves a healthier future. We create best-in-class vaccines that prevent disease and protect lives.

  • Innovation drives us. From AI and mRNA to next-gen science, we push the boundaries to deliver first- and best-in-class vaccines for infectious diseases worldwide.

  • Growth happens here. With bold investments in R&D and world-class facilities, Sanofians across the entire vaccine lifecycle are shaping the future of global health.

  • We do what’s right. Sustainability and DE&I drive our positive global impact—because the diverse communities Sanofians represent are the patients we serve.

All-in on diversity

At Sanofi, diverse perspectives fuel the best solutions for patients. Hear from Monique Vessey, our Supply Chain Transformation Leader, on how her background shapes her approach to delivering life-changing medicines.

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"Manufacturing and Supply is the bridge between the science that happens in research laboratories and the people and communities we serve."

Brendan O’Callaghan

Executive Vice President of Manufacturing and Supply

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Manufacturing & Supply Careers

Explore how Sanofi is transforming pharmaceutical manufacturing and supply chains with cutting-edge technology, digital innovation, and sustainable practices. Discover career opportunities where you can help deliver life-changing medicines efficiently and responsibly.

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