R&D
Where your curiosity drives the
miracles of
science
Postdoctoral fellow in structural biology and NMR spectroscopy
At a glance
Bring your curiosity to a team where deep immunoscience meets cutting-edge innovation. Across oncology, rare diseases, neurology, and vaccines, you’ll work at the intersection of lab science and AI-powered discovery — all while collaborating across boundaries to turn breakthrough ideas into real-world impact. Whether you want to deepen your scientific expertise or grow as a leader, you’ll find the opportunity here.
Job title: postdoctoral fellow – Structural biology / NMR spectroscopy
● Location: Vitry-sur-Seine
About the job
As a Postdoctoral Fellow in the Biophysics & BioNMR / BioAnalytics team, you will investigate how Post Translational Modifications (PTMs) in antibody CDRs affects antigen binding and molecular stability.
This project aims to develop a comprehensive methodology combining experimental structural biology (2D/3D-NMR, cryo-EM, crystallography, HDX-MS) with computational modelling to elucidate how PTMs in CDR modulate Fab structure and antigen recognition.
Your work will directly support molecule optimization and manufacturing process development.
About Sanofi:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
Main responsibilities:
- Produce and characterize samples with different levels of modification by mass spectrometry, SEC, DSC and binding assays.
- Perform 2D-NMR analysis on modified and unmodified mAb/Fab samples to map chemical shift perturbations and identify structural signatures induced by PTMs.
- Produce samples via cell-free expression.
- Structurally characterize the Fab-antigen interaction by NMR, cryo-EM, crystallography and HDX-MS data, to provide an integrated view of how PTMs modulate binding and stability.
- Design, produce and evaluate mutated Fab constructs to determine the role of residues neighboring the PTMs binding affinity and molecular stability.
- Present findings to cross-functional teams and contribute to scientific publications.
About you
- Education: PhD in NMR spectroscopy, structural biology, biophysics or a related field
- Experience & technical skills: Hands-on expertise in protein production including U-¹³C, ¹⁵N and ²H isotope labelling and specific methyl labelling; proven experience in NMR assignment of high molecular weight proteins (backbone and methyl groups)
- Languages: Fluent English, intermediate level of French
- Soft skills: Strong analytical mindset, curiosity, autonomy, and ability to collaborate within a multidisciplinary team
Why choose us?
- Learn from inspiring mentors and collaborative teams while contributing to real projects that shape the future of healthcare.
- Launch your career with a company that invests in you — and empowers you to reimagine what’s possible.
- Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science to spark new ideas and drive breakthroughs.
- Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
- Join a workplace where diversity, equity, and inclusion are at the core, with Employee Resource Groups and leadership programs that celebrate every voice.
PursueProgress. Discover Extraordinary.
Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.
Pursue Progress. Discover Extraordinary.
Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.
Find out more about this location
Why work with us
- Expand your horizons. Grow through curiosity, with support to move, learn, and lead in a culture that champions mentorship, mobility, and bold development.
- Accelerate results with technology. Harness the power of AI and automation to push scientific boundaries and reimagine what's possible in drug discovery.
- Impact through inclusive innovation. Help deliver better science and fairer outcomes by driving inclusive research that reaches more people, in more meaningful ways.
- Turn patient needs into breakthrough science. Drive scientific breakthroughs that start with patient needs – and end in treatments that change lives.
Meet Nils Libert, Associate Scientist
Meet Nils Libert, an Associate Scientist in Belgium, where he plays a key role in advancing groundbreaking research. Learn how his work helps drive innovation, uncover new scientific possibilities, and contribute to life-changing treatments that impact patients around the world.
Discover more
Our R&D focus areas
Discover how we're reshaping the future of medicine through immunoscience – unlocking bold, cross-disease breakthroughs that were unimaginable just a decade ago.
Meet Sanofians in the labs
Step inside our labs and hear from the scientists turning cutting-edge science into real-world impact – driven by curiosity, collaboration, and purpose.
Join our
talent community
What could we achieve together? Every Sanofian works on projects that truly make a difference to people’s lives.
Sign up today and discover our latest opportunities as soon as they’re available.