R&D
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Job Title: Senior Scientist

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

The Non-Viral Gene Therapy (NVGT) group within the Genomic Medicine Unit (GMU) of Sanofi creates innovative drug delivery modalities for treating a diverse set of diseases. The NVGT group specifically is responsible for engineering, formulating, analyzing, and assessing efficacy of lipid nanoparticle (LNP) based therapeutics.  

Sanofi is seeking a highly motivated Senior Scientist to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve LNP delivery to a diverse set of cell and tissue types.  

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?​

Main Responsibilities:

• Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues. 

• Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry. 

• Execute LNP/targeted LNP associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin 

• Design protein and antibody molecules at the primary sequence level 

• Support management of CRO for molecule production 

• Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data 

• Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members. 

• Plan, execute, and record experiments as guided in a time sensitive manner. 

• Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory. 

• Author standard operating procedures, study plans and reports and present findings. 

• Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture. 

About You

Requirements:

• PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 5 years of relevant industry experience. 

• Direct experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization is required. 

• Direct experience with site-specific bioconjugate chemistry is required. 

• Strong analytical biochemistry experience for protein and antibody engineering is required. 

• Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins 

• Experience with automation and high throughput platform(s) is preferred. 

• Experience with Biolayer Interferometry or equivalent technique is preferred. 

• Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience 

• Preferred familiarity with formulation and analysis of lipid nanoparticles for research use 

• Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting. 

• Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn. 

• Demonstrated ability to independently design, execute, interpret, and present experimental results. 

• Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment. 

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com