Principal Scientist, Systems and Disease Biology

Job Title: Principal Scientist, Systems and Disease Biology

• Location: Cambridge, MA

About the Job

As a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate the path from discovery to patient impact. Ready to get started?

The Systems and Disease Biology Cluster, part of the Target, Disease, and Systems Biology function at Sanofi Research, is dedicated to delivering first-in-class medicines to patients. Our approach involves deconstructing disease mechanisms into pathways & cellular building blocks and advancing innovative therapeutics.

We are in search of a highly skilled, independent, proactive, and well-organized Principal Scientist. The ideal candidate will possess expertise in complex cellular analytics, as well as strong data science skills to help build upon our current achievements and secure our future success. Experience in developing and deploying modern agentic analysis workflows to accelerate discovery timelines and create robust and reusable analytical templates is highly valued. Importantly, they should have the ability to creatively lead projects and coordinate scientific activities, summarize and present results, and establish their relevance to key decision points in the drug discovery process. Opportunities to mentor interns, and junior scientists may be available.

Join the engine of Sanofi’s mission — where deep immuno-science meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

• Generating hypotheses on how targets, pathways cell type/state drive diseases (immunology, neurology and oncology disease areas) by integrating multi-omics and multi-modal data, including real-world data and clinical metadata.

• Applying established analytical methods to understand disease and drug mechanisms.

• Design intelligent agentic workflows that streamline the deployment of innovative algorithms and computational models.

• Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics)

• Collaborating with academic, industry, and internal partners on method development and disease-focused scientific studies.

• Leading and contributing to high-profile presentations and publications.

• Support the growth of the team by mentoring interns and junior scientists, sharing knowledge and fostering a collaborative research environment.

About You:

• Ph.D. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology.

• At least 2 years of post-doctoral experience in relevant academic or industry roles.

• Hands-on experience in ML/AI and building or deploying agentic analysis workflows.

• Extensive hands-on experience and deep knowledge of multi-omics and/or multimodal data analysis, with ability to extract actionable interpretation and conclusions from the analysis.

• A track record of productivity, innovation and impact (publications or patents)

• Excellent communication, organizational, interpersonal and team skills; track record of success working collaboratively across disciplines.

Why Choose Us 

• Bring the miracles of science to life alongside a supportive, future-focused team. 

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. 

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. 

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. 

• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. 

• Help improve the lives of millions of people globally by making drug development quicker and more effective. 

• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. 

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.