R&D
Là où votre curiosité fait avancer les miracles de la science

Job Title: Head of Global Investigative Toxicology

Location: Cambridge, MA

About the Job

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

In the pharmaceutical industry, one of the major challenges in the discovery of innovative medicines is to ensure they are safe enough to serve patients – that is our mission. Drug safety is assessed throughout the R&D value chain, but it is during early drug discovery when we can actively design safety attributes into future candidate drug. We are supporting Drug Hunting partners in identification and optimization of new biological and synthetic molecule series applying cutting edge technologies pushing to the boundaries of predictive safety science with our mission in mind. We are also committed to the application of the 3Rs principles and to the implementation of New Alternative Methodologies (NAMs) in preclinical safety assessment.

About Sanofi:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

For our global investigative toxicology efforts we are looking for a strong Leader with focus on Investigative Toxicology. Activities include, but are not limited to:

• Leading our global  investigative toxicology efforts with operations in Boston, Paris and Montpellier and with Senior Scientific Advisors serving as global safety experts in various toxicology disciplines based in multiple countries (France, US and Germany); develop/evolve strategy, ensure alignment and rationalization of activities across sites; ensure reaching out to internal and external ecosystem to develop/maintain networks and ensure access to appropriate methodologies/vendors; reach to other functions in R&D (Translational Medicine Unit, Research and Development) to share technologies / use synergies as applicable. Advice Preclinical Safety Project teams reps on building investigative toxicology strategy / review given strategies to progress projects successful overcoming challenges or rationale termination.

• Reporting to global Head PCS and Member of the global Leadership Team.

• Manage Senior Scientific Advisors globally.

• Strongly interact with Heads of Research Projects and Development projects

• Develop together innovative solutions and research proposals to pursue cutting edge science and technologies in order to optimize and influence translational safety assessment of novel drug targets.

• Facilitate and promote the use of new alternative methods (NAMs) in preclinical safety regulatory and non-regulatory testing.

• Serve globally as internal expert for discovery and development projects and design project-specific strategies to predict, assess and mitigate target- and modality-related safety risks and execute through internal and external experimental capabilities.

• Engage with experts across the organization to ensure that teams are able to make the right decisions regarding the translational safety risks associated with the project.

• Continuously interact with multiple R&D functions (TMU departments, Research and Development TAs, Research Platforms, etc ..) to identify opportunities to collaborate and utilize technologies across R&D more efficiently.

• Participate in special projects or inter-industry working groups, as needed.  Provide scientific input on design and analysis of research activities and contribute to Sanofi Outreach activities.

• Ensure high scientific standards / adhering to requested timelines in all aspects of the position.

• Supervision / Development of laboratory staff and global experts.

About You

Basic Qualifications:

• PhD or DVM and post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology or systems biology. In addition, the candidate should have knowledge in biochemistry, toxicology, pharmacology, biology, physiology, and pathology.

• Solid understanding of the drug discovery and development process based on more than 20 years of experience in pharmaceutical industry in nonclinical drug safety and investigative toxicology.

• Demonstrated knowledge and experience investigating molecular mechanisms of drug action is critical.

• Experience with the design and execution of in vitro/in vivo experiments to determine the effects of therapeutics on biological systems, with line of sight to human safety risk understanding.

• Knowledgeable about regulatory nonclinical testing requirements for pharmaceutical development of biologics and small molecules.

• Strong leadership competencies (as direct manager and transversal leader in a global and complex environment) and demonstrated experience.

Preferred Qualifications:

• Highly motivated, creative, innovative, reliable scientist, with a flexible, collaborative, team-oriented mindset, who solves problems in a goal-focused fashion.

• A social personality that contributes to an open, positive, collaborative working climate.

• Strong communication, presentation and influencing skills across levels/disciplines.

• DABT certification and experience as GLP Study Director is preferred, but not required.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Toujours Progresser. Découvrir l’Extraordinaire.

Rejoignez Sanofi et entrez dans une nouvelle ère de la science – où votre parcours peut être aussi transformateur que le travail que nous accomplissons. Nous investissons en vous pour que vous alliez plus loin, accélériez votre réflexion et accomplissiez ce qui n’a jamais été fait auparavant. Vous contribuerez à repousser les limites, à bousculer les conventions et à concevoir des solutions plus intelligentes pour les communautés que nous servons. Prêt·e à poursuivre les miracles de la science et à améliorer la vie des gens ? Poursuivons le progrès et découvrons l’extraordinaire – ensemble.

Chez Sanofi, nous croyons dans l’égalité des chances, sans distinction de race, de couleur, d’ascendance, de religion, de sexe, d’origine, d’orientation sexuelle, d’âge, de citoyenneté, d’état civil, de handicap, d’identité de genre ou de tout autre critère protégé par la loi.